Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

Abstract Background The topical inflammatory soup can model the inflammation of dura mater causing hypersensitivity and activation trigeminal system, a phenomenon present in migraineurs. Calcitonin gene-related peptide, transient receptor potential vanilloid-1 receptor, neuronal nitric oxide synthase are important sensitization process there. 5-HT 1B/1D agonists, triptans used as treatment migraine. Kynurenic acid an NMDA antagonist act on structures involved activation. Aim We investigated effect induced dural calcitonin levels caudal nucleus. also tested whether pretreatment with well-known antimigraine drug, such sumatriptan kynurenic acid, compound different mechanism action, affect these changes if their modulatory effects comparable. Material methods After subcutaneous or intraperitoneal adult male Sprague-Dawley rats ( n = 72) was treated its vehicle (synthetic interstitial fluid). Two half four hours later perfusion performed nucleus removed for immunohistochemistry. Results conclusion Inflammatory increased compared to placebo, which attenuated by acid. This suggests involvement receptors neurogenic development thus migraine attacks.